Auszug aus der wissenschaftlichen Literatur zu Phloridzin und Phloretin:
Literatur Phloridzin (Phlorizin) und Phloretin:
THE JOURNAL of CHEMISTRY Vol. 234, No. 11, November 1959 Printed in U.S.A.
The Attachment of Phloretin and Analogues to Human Ervthrocvtes in Connection with Inhibition J J of Sugar Transport*
PAUL G. LEFEVRE AND JANE K. MARSHALL
From the Medical Research Center, Brookhaven National Laboratory, Upton, New York
(Received for publication, July 13, 1959)
In passing through the surface of mammalian erythrocytes, the common monosaccharides evidently make use of a special “carrier” system (l-6) which is strongly inhibited by phloretin, the aglucon of phlorhizin (2, 7). In most species, the activity
Eur J Clin Invest. 1975 Jun 12;5(3):285-8.
Is phlorizin or its aglycon the inhibitor of intestinal glucose transport? A study in normal and lactase deficient man.
Inhibition of glucose transport by phlorizin was examined in man by perfusion of an isolated small bowel segment. Inhibition was similar in normal and lactase deficient subjects. Since the small bowel of lactase deficient subjects contains only very small amounts of phlorizin hydrolase, phlorizin and not a product of enzymatic cleavage is the inhibitor of the small intestinal glucose carrier.
Gastroenterology. 1993 Sep;105(3):692-7.
Inhibition of glucose absorption by phlorizin affects intestinal functions in rats.
Department of Nutrition, School of Medicine, University of Tokushima, Japan.
To investigate the mechanism of regulation of intestinal disaccharidase activity and glucose absorption, the effect of dietary intake of phlorizin, a potent and specific inhibitor of intestinal glucose transport, on intestinal disaccharidase activity and Na(+)-dependent glucose transporter was examined in rats.
Jejunal disaccharidase activity and the number of Na(+)-dependent glucose transporters were determined in rats maintained on a low-starch diet, a high-starch diet, or low-starch diets containing various amounts of phlorizin (0.1%-0.9% wt/wt).
Jejunal disaccharidase activity increased in a dose- and time-dependent manner. Stimulation of jejunal disaccharidase activity only occurred when phlorizin was added to starch-containing diets, not when it was added to a carbohydrate-free diet. Addition of the same amount of phloretin and glucose (constituents of phlorizin), to the diet failed to increase disaccharidase activity. The maximum binding of phlorizin to brush border membrane vesicles was increased in the rats fed phlorizin, whereas the dissociation constant remained unchanged, suggesting an increase of glucose transporter expression.
Dietary phlorizin increased the jejunal disaccharidase activity and Na(+)-dependent glucose transporter expression. The trigger for these changes may have been due to an increased luminal glucose content.
BIOCHIMICA ET B1OPHYSICA ACTA 145 BBA 76051
AN EXAMPLE OF MUTUAL COMPETITION BETWEEN TRANSPORT INHIBITORS OF DIFFERENT KINETIC TYPE: THE INHIBITION OF INTESTINAL TRANSPORT OF GLUCALOGUES BY PHLORETIN AND PHLORIZIN
V. E. COLOMBO AND G. SEMENZA
Department of Biochemistry of the Swiss Federal Institute of Technology (E.T.H.), Zurich (Switzerland) (Received May i8th, 1972)
SUMMARY I. Kinetic analysis allows the detection of mutual competition between transport inkibitors of similar or of different kinetic type. 2. Phlorizin, a fully competitive and phloretin, a fully non-competitive inhibitor compete mutually for the transport system(s) of glucalogues in hamster small intestine. This observation suggests common step(s) in the mechanism of inhibition by phloretin and phlorizin.
Phloridzin is the specific and competitive inhibition of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). This property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. Phloridzin is one of the dihydrochalcones typically contained in apples and in apple-derived products. The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats. As a well-known consequence of becoming diabetic, urine volume and water intake were significantly increased. Administration of phloridzin reduced urine volume and water intake in a dose-dependent manner. Phloretin decreases of food consumption, as well as a marked lowering in the weight. In conclusion, this compound could be proposed as an antihyperglycemic and antihyperlipidemic agent in diabetes and potential therapeutic in obesity.